منابع مشابه
Topologically fixed SecG is fully functional.
It has been proposed that the bitopic membrane protein SecG undergoes topology inversion during translocation of (pre)proteins via SecYEG. Here we show that SecG covalently cross-linked to SecY cannot invert its topology while remaining fully functional in protein translocation. Our results strongly disfavor topology inversion of SecG during protein translocation.
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ژورنال
عنوان ژورنال: Nature Reviews Genetics
سال: 2002
ISSN: 1471-0056,1471-0064
DOI: 10.1038/nrg896